![ichorbio/Alirocumab Biosimilar – Research Grade [ICH4016]/50mg/ICH4016](images/ichorbio/Western20Blot20of20Anti-CD8020In20Vivo20Antibody20-20Low20Endotoxin205B16-10A15D20ICH1037-1.jpg)
Bulk Alirocumab Biosimilar – Research Grade
Product Benefits:
ichorbio’s Alirocumab Biosimilar – Research Grade is manufactured in a cGMP compliant facility. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
Size:
ichorbio’s research grade alirocumab biosimilar is available in the following sizes:5mg, 10mg, 20mg, 50mgichorbio regularly manufactures bulk multi-gram amounts of our alirocumab biosimilar – please contact us for pricing.
Target:
PCSK9
Clone:
n/a
Isotype:
IgG1
Other Names:
Proprotein convertase subtilisin/kexin type 9, NARC-1, PC9
Host:
Humanized
Species Reactivity:
Human
Specificity:
Detects human PCSK9. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Alirocumab.
Purification Method:
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background:
Alirocumab biosimilar is a human monoclonal antibody (IgG1 isotype) that targets proprotein convertase subtilisin kexin type 9 (PCSK9), is a PCSK9 inhibitor produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture. Alirocumab biosimilar consists of two disulfide-linked human heavy chains, each covalently linked through a disulfide bond to a human kappa light chain. A single Nlinked glycosylation site is located in each heavy chain within the CH2 domain of the Fc constant region of the molecule. The variable domains of the heavy and light chains combine to form the PCSK9 binding site within the antibody. Alirocumab biosimilar has an approximate molecular weight of 146 kDa.
Concentration:
1.0 – 5.0 mg/ml
Formulation:
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
Purity:
>95% by SDS-PAGE and HPLC
Endotoxin:
≤ 0.75 EU/mg as determined by the LAL method
Storage:
Alirocumab Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:
Functional Assays
Application Notes:
Each investigator should determine their own optimal working dilution for specific applications.
Use:
![ichorbio/Anti-CD278 In Vivo Antibody – Low Endotoxin (7E.17G9) [ICH1082]/100mg/ICH1082](images/ichorbio/Low-Endotoxin-in-vivo-antibody-ichorbio-1-247x296.png)
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