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Bulk Alemtuzumab Biosimilar – Research Grade – Fc-Silenced
Product Benefits:
This biosimilar is manufactured in a cGMP compliant, ISO Quality Standard 9001:2015 facility. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
Target:
CD52
Clone:
Campath-1H
Isotype:
Human IgG1 κ
Host:
Human
Species Reactivity:
Human/Rhesus Monkey/Cynomolgus Monkey
Specificity:
This non-therapeutic biosimilar antibody uses the same variable region sequence as the therapeutic antibody Alemtuzumab. Clone Campath-1H recognizes human CD52.
Antigen Distribution:
CD52 is primarily expressed on the surface of mature lymphocytes. Additionally, CD52 is present on most lymphoid derived malignancies. However, variable expression on Myeloma cells should be noted.
Background:
Clone Campath-1H is a monoclonal antibody that specifically binds to CD52, a protein present on the surface of mature lymphocytes. However, this protein is not present on the stem cells that generated these lymphocytes. Alemtuzumab is targets and destroys mature lymphocytes containing CD-52, and is used to treat chronic lymphocytic leukemia (CLL) and multiple sclerosis. Anti-Human CD52 (Alemtuzumab) utilizes the same variable regions from the therapeutic antibody Alemtuzumab making it ideal for research projects.
Immunogen:
Human lymphocytes
Concentration:
≥ 2.0 mg/ml
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 – 7.4, 150 mM NaCl with no carrier protein, potassium, calcium or preservatives added.
Purity:
>99% by SDS-PAGE and HPLC
Endotoxin:
<0.5 EU/mg as determined by the LAL method
Storage:
This biosimilar is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:
CyTOF®, ELISA, Functional Assays, Flow Cytometry, Immunohistochemistry FF, Immunohistochemistry FFPE, Western Blotting
Application Notes:
Each investigator should determine their own optimal working dilution for specific applications.
Isotype Control:
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
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