![ichorbio/Ado-trastuzumab emtansine Biosimilar – Research Grade [ICH4014]/20mg/ICH4014](images/ichorbio/Western20Blot20Anti-IFN20beta20In20Vivo20Antibody20-20Low20Endotoxin205BHDB-4A75D20ICH1110-1.jpg)
Bulk Ado-trastuzumab emtansine – Research Grade
Product Benefits:
ichorbio’s Ado-trastuzumab emtansine Biosimilar – Research Grade is manufactured in a cGMP compliant facility. ichorbio offers Amazon vouchers or donations to the NC3Rs for reviews of this product: click here for more information. ichorbio: the best antibodies for in vivo research.
Size:
ichorbio’s research grade ado-trastuzumab emantsine biosimilar is available in the following sizes:5mg, 20mgichorbio regularly manufactures bulk multi-gram amounts of our ado-trastuzumab emantsine biosimilar – please contact us for pricing.
Target:
ErbB2
Clone:
n/a
Isotype:
IgG1
Other Names:
Receptor tyrosine-protein kinase erbB-2, MLN 19, HER2, HER2/neu
Host:
Humanized
Species Reactivity:
Human
Specificity:
Detects human HER2. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Ado-trastuzumab emtansine. .
Purification Method:
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background:
Ado-trastuzumab emtansine is a HER2-targeted antibody-drug conjugate which contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the microtubule inhibitory drug DM1 via the stable thioether linker MCC. Trastuzumab is produced by Chinese hamster ovary cells, and DM1-MCC are produced by chemical synthesis. Ado-trastuzumab emtansine contains an average of 3.5 DM1 molecules per antibody.
Concentration:
1.0 – 5.0 mg/ml
Formulation:
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and Azide free.
Purity:
>95% by SDS-PAGE and HPLC
Endotoxin:
≤ 0.75 EU/mg as determined by the LAL method
Storage:
Ado-trastuzumab emtansine Biosimilar – Research Grade is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Applications:
Functional Assays
Application Notes:
Each investigator should determine their own optimal working dilution for specific applications.
Use:
![ichorbio/Anti-CD278 In Vivo Antibody – Low Endotoxin (7E.17G9) [ICH1082]/100mg/ICH1082](images/ichorbio/Low-Endotoxin-in-vivo-antibody-ichorbio-1-247x296.png)
![ichorbio/Alirocumab Biosimilar – Research Grade [ICH4016]/50mg/ICH4016](images/ichorbio/Western20Blot20of20Anti-CD8020In20Vivo20Antibody20-20Low20Endotoxin205B16-10A15D20ICH1037-1.jpg)
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